飞禽走兽是什么意思

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                                    XIAOHUIKETIZUFAXIANcGAMPKUAXIBAOJIHUOSTINGKANGBINGDUGANRANXINJIZHI

                                      

                                      4YUE10RI,GUOJIXUESHUQIKANImmunityZAIXIANFABIAOLEZHONGGUOKEXUEYUANSHANGHAIBASIDEYANJIUSUOXIAOHUIKETIZUDEYANJIULUNWEN“Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels (VRACs) Augments STING-Mediated Interferon Responses and Anti-viral Immunity”。GAIYANJIUFAXIANYINLIZITONGDAOLRRC8/VRACSHIYIGEKUAXIBAOMOZHUANYUNcGAMPDEZHUANYUNDANBAI,NENGJIANGBINGDUGANRANXIBAOCHANSHENGDEcGAMPZHUANYUNDAOFEIGANRANXIBAOZHONGJIHUOSTINGXINHAOHEGANRAOSUYINGDA。ZHEIYIFAXIANZHANSHICHUJITIDIYUBINGDUGANRANDEDUTEJIZHI,YEWEIYIMIAOYANFAHEMIANYIZHILIAOTIGONGLEXINSILU。  

                                      DNA模式识别受体cGAS识别病毒感染细胞或肿瘤细胞中出现在胞浆中的双链DNA后,催化合成二级信使cGAMP。cGAMP通过与内质网ER上的接头分子STING结合激活TBK1/IRF3信号通路,诱导I型干扰素IFN表达,启动宿主防御或肿瘤免疫。虽然传统观念认为cGAMP的作用应该局限于合成它的细胞内,但最近一些证据表明cGAMP也能在细胞间转运,特别是从病毒感染细胞或肿瘤细胞中转移到旁观者细胞中(bystander cells)激活STING并诱导IFN表达。但在病毒感染条件下,细胞转运cGAMP的分子机理和生理意义还不清楚。LRRC8/VRAC是五年前才被发现的调控低渗反应和细胞体积的阴离子通道,由LRRC8A和它的同源亚基LRRC8B-E形成异源性六聚体行使功能。VRAC在低渗透压下被迅速激活,介导Cl-外流来降低细胞内渗透压、防止细胞膨胀。除了运输氯离子,VRAC还能转运一些有机分子,包括天冬氨酸和谷氨酸、神经递质GABA和抗癌药物顺铂,参与调节生长发育或影响糖尿病和中风。 

                                    飞禽走兽是什么意思  XIAOHUIZUYANJIURENYUANTONGGUOTIWAISHAIXUANYIWAIDIFAXIANDIAOJIEDISHENFANYINGDEYINLIZITONGDAOLRRC8/VRACZAIKANGPAOZHENBINGDUHSV-1GANRANZHONGQIZHONGYAOZUOYONG。TONGGUOMOPIANQIANDIANSHENGLIJISHUHEYEXIANGSEPU-ZHIPULIANYONGJISHU,DINGXINGHEDINGLIANGDIZHENGMINGLEVRACSHIYIGEcGAMPZHUANYUNDANBAI,TANENGSHUNZHENONGDUTIDUCHUANDAOcGAMPXIANGXIBAOWAIPAI(efflux)HUONEILIU(influx)。CHULEDISHENTIAOJIAN,YANJIURENYUANFAXIANYANZHENGYINZITNFHEIL-1YENENGJIHUOVRAC。YINCIZAIBINGDUGANRANSHI,VRACBEIYANZHENGYINZIJIHUOHOU,NENGJIANGBINGDUGANRANXIBAOHECHENGDEcGAMPZHUANYUNCHULAI,TOUGUOtranswellZHUANYIDAOGONGPEIYANGDEWEIGANRANXIBAOZHONG,JIHUOSTINGBINGYOUDAOIFNBIAODA。ZAIVRACJIYINQIAOCHUDEXIAOSHUZHONG,HSV-1GANRANYOUDAODEIFNFANYINGJIANGDI,BINGDUZAILIANGZENGGAO,BIAOMINGcGAMPZAIPANGGUANZHEXIBAOZHONGYOUDAODEIFNZAIDIYUHSV-1BINGDUGANRANZHONGZHIGUANZHONGYAO。GAIYANJIUBUJINJIESHILELRRC8/VRACDIAOKONGcGAMPZHUANYUNDEZUOYONGJIZHIHESHENGLIGONGNENG,ERQIEWEIYANFAKANGBINGDUYIMIAO、YOUHUAZHONGLIUMIANYIZHILIAOTIGONGLEXINSILU。 

                                      

                                      ZHONGGUOKEXUEYUANDAXUEBOSHIYANJIUSHENGZHOUCHUN、LANZHOUDAXUE/SHANGHAIBASIDEYANJIUSUOLIANHEPEIYANGBOSHISHENGCHENXIA、DEGUOLAIBUNICIFENZIYAOLIYANJIUSUOBOSHIHOURosa Planells-CasesWEILUNWENDEGONGTONGDIYIZUOZHE,XIAOHUIYANJIUYUANHEDEGUOLAIBUNICIFENZIYAOLIYANJIUSUOThomas J. JentschJIAOSHOU、MEIGUOYUEHANSIHUOPUJINSIDAXUEYIXUEYUANDEZhaozhu QiuJIAOSHOUWEILUNWENDEGONGTONGTONGXUNZUOZHE。GAIYANJIUDEDAOLEGUOJIAKEJIBUZHONGDIANYANFAJIHUA、GUOJIAZIRANJIJINWEI、ZHONGGUOKEXUEYUANGUOJIHEZUOZHONGDIANXIANGMUHEZHANLVEXINGXIANDAOZHUANXIANGDEZIZHU。

                                      QUANWENLIANJIE:

                                    飞禽走兽是什么意思  TUSHI:cGAMPTONGGUOLRRC8/VRACCONGBINGDUGANRANXIBAOZHUANYUNDAOWEIGANRANXIBAOZHONGJIHUOSTINGHEIFNDEMOSHITU。

                                      

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